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Psychopharm Commandment 4: Lamotrigine Rash

October 24, 2022

Chris Aiken, MD and Kellie Newsome, PMHNP

How to assess, treat, and when you can restart after a lamotrigine rash.

In Brief: Lamotrigine Gets a New Warning

May 4, 2021

Chris Aiken, MD, and Sarah Rivelli, MD.

Chris Aiken, MD, and Sarah Rivelli, MD. Dr. Aiken and Dr. Rivelli have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

A new warning now sits beneath the list of life-threatening allergic reactions that can happen with lamotrigine. The anticonvulsant is suspected of causing cardiac arrhythmias in susceptible patients by slowing ventricular conduction and widening the QRS.

Pros and Cons of Using Oxcarbazepine Over Carbamazepine

August 28, 2020

Does the limited research support that oxcarbazepine is a safer and more effective treatment for bipolar disorder than its FDA-approved cousin, carbamazepine? Here is an overview of the pros and cons from a previous article in The Carlat Psychiatry Report.Pros:Similar effectiveness as other mood stabilizers. In mania and mixed states,...

Oxcarbazepine: Close, but no Cigar

March 9, 2020

Oxcarbazepine is thought of as a kinder, gentler cousin of carbamazepine, but it brings new safety issues of its own and does not fully escape the drug interactions that hinder carbamazepine. We pull on the published and unpublished trials to figure out where this anticonvulsant stands in bipolar disorder.