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IM Olanzapine Plus Benzodiazepines: Safe or Unsafe?

September 13, 2021

Victoria Hendrick, MD. and Daniel Carlat, MD

Victoria Hendrick, MD. Editor in Chief, The Carlat Hospital Psychiatry Report. Chief, Inpatient Psychiatry, Olive View UCLA Medical Center.

Daniel Carlat, MD. Publisher, The Carlat Hospital Psychiatry Report.

Dr. Hendrick and Dr. Carlat have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

If you have ever tried to electronically prescribe IM olanzapine with an IM/IV/subcutaneous benzodiazepine, you have probably received an interaction alert warning about the potential for excessive sedation and cardiorespiratory depression. Is this warning justified? Let’s look at the data.

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