side-effects | CARLAT PUBLISHING

Tricyclic Antidepressants: When and How to Use Them

May 1, 2022

Edmund S. Higgins, MD. Clinical associate professor, Psychiatry and Behavioral Sciences, Medical University of South Carolina. Dr. Higgins has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Tricyclics have been used in psychiatry since the 1950s, when imipramine was introduced as the first mass-marketed antidepressant. Fluoxetine and the other SSRIs largely supplanted the tricyclics in the 1990s, but these medications still have their uses.

Thyroid Augmentation in Bipolar Disorder

April 5, 2022

Tammas Kelly, MD.

Tammas Kelly, MD. Clinical Assistant Professor of Psychiatry at the Jacobs School of Medicine and Clinical Associate Professor of Psychiatry at the George Washington University School of Medicine. Author of The Art and Science of Thyroid Supplementation for the Treatment of Bipolar Depression. Dr. Kelly has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

A primer on the role of thyroid augmentation in bipolar depression, including dosing tips, side effects, interactions, and when and if to perform labs. With Tammas Kelly, MD.

RESEARCH UPDATE

Anticholinergic-Associated Cognitive Impairment in Schizophrenia

April 5, 2022

Brian Miller, MD, PhD, MPH.

Brian Miller, MD, PhD, MPH. Dr. Miller has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Antipsychotics, benztropine, and antidepressants have anticholinergic properties that can impair cognition. A study takes a deep dive into the magnitude of the risk of dementia in schizophrenia.

Sublingual Atropine Drops and Clozapine-Induced Drooling

March 23, 2022

Sébastien Hardy, PharmD, BCPS.

Sébastien Hardy, PharmD, BCPS. Dr. Hardy has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Sialorrhea, or excessive salivation, is a distressing side effect from clozapine. Sublingual atropine drops help reduce clozapine-induced hypersalivation.

Lybalvi: The Diet Olanzapine

January 31, 2022

Chris Aiken, MD.

Chris Aiken, MD. Editor-in-Chief, The Carlat Psychiatry Report.

Lybalvi hopes to lower the risk of weight gain on olanzapine by combining it with an opioid blocker (samidorphan). But how does it compare to generic options like metformin and naltrexone?

Sleepwalking on Antipsychotics and Lithium

November 5, 2021

Thomas Jordan, MD.

Thomas Jordan, MD. Dr. Jordan has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Sleepwalking is a rare side effect on psychiatric medications, particularly hypnotics and antidepressants. A new analysis explores whether lithium and the antipsychotics should be added to that list.

IM Olanzapine Plus Benzodiazepines: Safe or Unsafe?

September 13, 2021

Victoria Hendrick, MD. and Daniel Carlat, MD

Victoria Hendrick, MD. Editor in Chief, The Carlat Hospital Psychiatry Report. Chief, Inpatient Psychiatry, Olive View UCLA Medical Center.

Daniel Carlat, MD. Publisher, The Carlat Hospital Psychiatry Report.

Dr. Hendrick and Dr. Carlat have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

If you have ever tried to electronically prescribe IM olanzapine with an IM/IV/subcutaneous benzodiazepine, you have probably received an interaction alert warning about the potential for excessive sedation and cardiorespiratory depression. Is this warning justified? Let’s look at the data.

Comparison of GI Side Effects of Antidepressants

August 3, 2021

Jesus Ligot, MD.

Jesus Ligot, MD. Dr. Ligot has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Modern antidepressants are ranked by their risk of GI side effects, with a few surprises baked in.

Battle of the Bulge: Obesity and Antipsychotic-Induced Weight Gain

July 14, 2021

Farah Khorassani, PharmD. Clinical Assistant

Farah Khorassani, PharmD. Clinical Assistant Professor of Pharmacy Practice, St. John’s University, Queens, NY. Dr. Khorassani has disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

With so many weight loss medications on the market, it’s hard to know which to choose. Dr. Khorassani tells us everything we need to know to about selecting and prescribing these agents. Also, she gives us additional tips for managing antipsychotic-induced weight gain.

Weight Gain and Metabolic Side Effects

July 14, 2021

Stephen Marder, MD

Stephen Marder, MD

Daniel X. Freedman Professor of Psychiatry. Vice Chair for Education, Semel Institute for Neuroscience at UCLA. Director, VA VISN 22 Mental Illness Research, Education, and Clinical Center, San Diego, CA.

Dr. Marder has disclosed no relevant financial or other interests in any commercial companies pertaining to educational activity.

Dr. Steve Marder describes interventions to minimize patients’ antipsychotic-induced weight gain and insulin resistance.