Xyrem is a branded form of sodium oxybate, the sodium salt of gamma-hydroxybutyrate, or GHB , to precursor to GABA, glutamate, and glycine which is FDA approved for narcolepsy and cataplexy. The news on Xyrem is that the FDA just approved a new version of it – called Xywav – made...

We take you through the story of rational drug discovery that lead to the approval of guanfacine and clonidine for ADHD, and share some tips on how to use them. And the word of the day: Dyssymbole.Published On: 10/26/2020Duration: 19 minutes, 55 secondsArticle Referenced: "Guanfacine ER for Adults With ADHD?"...

The hand eye movements of a prescription video game are thought to exercise circuits involved in attention, and this theory did translate to small but real improvements in attention in 5 clinical trials involving over 600 children with ADHDPublished On: 10/24/2020Duration: 3 minutes, 4 secondsTranscript: A spaceman rides down an icy...

Last April we reported on Pimavenserin – Nuplazid – the novel antipsychotic that’s FDA approved in psychosis related to parkinson’s disease. In that article we mentioned a randomized controlled trial from Mass General – the CLARITY trial - that showed promising augmentation effects when Pimavenserin was added to an antidepressant...

We interview Ruta Nunacs on perimenopausal depression, and our word of the day – processomania – brings us into the crosshairs of politics and psychiatry.Published On: 10/18/20Duration: 24 minutes, 42 secondsArticle Referenced: "Mood and Menopause," The Carlat Psychiatry Podcast, October 2020Rough Transcript:Dr. Aiken: Women have twice the risk of depression as men. But...

New labeling from the FDA requires physicians to discuss naloxone with patients or caregivers they are prescribing opioids to. The new guideline also recommends that we prescribe naloxone to anyone who is at risk for opioid overdose, even if we aren’t prescribing them an opioid. That would include patients with...

Benzo prescriptions have risen 34% during COVID-19, particularly in women. People are also getting benzos outside of prescriptions. Drs. Islam and Choudhry discussed the emerging trend in a commentary in Clinical Psychiatry News. Specifically, they are concerned that people will obtain benzos over the internet, and that this casual use can...

Trintellix claims to improve cognition in depression, but what does this effect look like in patient’s lives? We speak with Tom Gualtieri about the cognitive side of antidepressants, and show you how to use a 3 minute cognitive test that reveals a lot about how your patients are functioning.Published On:...

A special edition for patients. Lithium is one of the most effective medications for bipolar and depression, but many of its marvels have remained obscure. Lithium has never benefited from a pharmaceutical ad (because it’s a mineral, not a medicine), so we’ve stepped in to fill that gap.Published On: 10/5/20Duration:...

When it comes to PTSD, pharmacotherapy is second-line and psychotherapy has the more robust evidence. The effect size for therapy is in the large range, while medications are in the small, with one exception…. In studies where patients are allowed to choose their preferred mode of treatment, those who prefer...