For nearly 17 years, since the FDA black box warning about suicidality with antidepressants, our community has been quoting data that downplays this concern. We were wrong. We were deceived. Antidepressants can be lifesaving, but there really is a duty to warn. In this episode, Doctors Martha Ignaszewski and Glen Spielmans...

In 2012, psychiatrists at Harvard’s Massachusetts General Hospital discovered a novel antidepressant. It seemed to improve depression and cognition without causing any significant side effects. There was only one problem. The ingredients were practically free, and there was no way that was going to sell.

Bupropion and restless legs syndrome: a randomized controlled trialWhen a patient complains that their mood got worse on an antidepressant, it doesn’t necessarily mean they are sensitive to medications. In this episode, we detail 6 other reasons why depression can get worse on an antidepressant.Published On: 2/15/21Duration: 22 minutes, 42 secondsArticle Referenced: "Are...

An interview with Swapnil Gupta on when and how to come off psychiatric medications. Plus, tips on cross-tapering antidepressants, and the word of the day: Ephedra.Published On: 2/8/2021Duration: 17 minutes, 1 secondTranscript:Today, an interview with Swapnil Gupta on when and how to come off psychiatric medications.Welcome to the Carlat Psychiatry Podcast, keeping...

Behavioral activation came about in the 1990’s as a challenge to the CBT model of depression. The basic strategy behind this therapy blends well with brief medication visits, and we explain how to use it in this professional guide. Check out the patient companion to this edition in the Pocket...

Richard Weisler tells the tale of science and serendipity that lead to his discovery of lamotrigine for bipolar depression 30 years ago. He shares a few dosing tips, and touches on how he works with patients and their families. Plus, the word of the day: Gramophone Syndrome.Published On: 1/25/21Duration: 23...

The Queen’s Gambit is Netflix’s critically acclaimed series about a chess prodigy who gets “a little help from her friends.” In this episode we find out what they got right, and wrong, about psychiatric meds and cognitive enhancement.Published On: 1/11/2020Duration: 29 minutesTranscript:Dr. Aiken: Cognitive problems are one of the most common complaints...

Brett Stevens has lived through the worst of bipolar and come out standing. Here’s what he did to get his life back. This is the first edition of The Pocket Psychiatrist, a monthly series you can share with your patients through a separate podcast stream.Published On: 1/4/2021Duration: 15 minutes, 24...

A look at the top 10 practice-changing highlights from our 2020 journal. Tardive dyskinesia, inflammation, lumateperone, top first-line medications, trazodone in depression, Silexan for anxiety, excellent lithium responders, hormones and mood, and ramelteon’s generic debut.Published On: 12/28/2020Duration: 26 minutes, 30 secondsArticles Referenced: "How to Treat Tardive Dyskinesia," The Carlat Psychiatry Report,...

Retractions are on the rise in medical research, and we get to the bottom of it with Ivan Oransky, cofounder of RetractionWatch.com.Published On: 12/21/2020Duration: 25 minutes, 12 secondsRough Transcript:Can you personalize antidepressant selection, use antipsychotics in dementia, or treat adolescent OCD with brain surgery? Yes, you can…. Oh wait – maybe...