This page has links and instructions for downloading your PDF and eBook copies of Difficult To Treat Depression: A Carlat Guide (2026) and completing the 12 CME Post-Test.

Do TMS and psychotherapy share a common mechanism? We talk with Owen Muir about how to engage patients with this magnetic therapy.

Second-generation antipsychotics have cut the risk of tardive dyskinesia (TD) in half—from 7% to 3% per year—but it is still a problem.

Lithium, pramipexole, bupropion, carbamazepine, valproate, and trazodone. Meds that require special skill to start: 

Meds that require special skill to start: Clozapine and lamotrigine.

Ziprasidone and quetiapine. One goes better fast, one slow. Also the mystery of ghost pills, and a research update on pramipexole.

The FDA just approved the cyclobenzaprine (Tonmya, Flexeril) for fibromyalgia. We look at three risks that medication raises in psychiatry.

The FDA just approved Ketarx for surgical pain, but the company has its eyes on depression.

Meds that require special skill to start: Atomoxetine and prazosin, plus a new FDA warning on stimulants.