The last high-quality head-to-head comparison of buprenorphine and methadone during pregnancy was the MOTHER trial, which was published nearly 15 years ago. Here, researchers revisited the question of which medication is better to use in pregnancy in this large, carefully done, retrospective study. The results make a compelling case for buprenorphine. 

Methadone treatment for OUD typically comes with a high level of supervision whereas buprenorphine is often flexibly dosed and taken at home. Here researchers wanted to know how patients of a closely supervised methadone clinic compared with those taking buprenorphine prescribed in an office setting. The findings might surprise you.

A dextromethorphan-bupropion combo tablet shows promise in treating major depression. The FDA recognized its potential in 2019, so stay tuned for more updates on this novel treatment.

A popular DIY therapy for depression (transcranial direct current stimulation) is tested in ADHD. 

Although intermittent theta-burst stimulation demonstrates efficacy in depression treatment, we look into how it addresses suicidality?

Incarcerated individuals with opioid use disorder are at an especially heightened risk of adverse outcomes.  The period immediately following release is a particularly vulnerable time, with a much elevated risk of fatal overdose. In this study, investigators report on the use of extended-release injectable buprenorphine in a correctional setting.

Despite its high prevalence, morbidity, and mortality, our treatment options for alcohol use disorder are limited. Severe alcohol use disorder can be especially challenging to treat. Here, researchers demonstrate the efficacy and feasibility of a novel treatment option: deep brain stimulation.