For decades, the principal treatment for substance use disorders has been psychological therapies. Twelve-step facilitation therapy, modeled after Alcoholics Anonymous, and motivational enhancement therapy are currently the two most widely used.Although disulfiram (Antabuse) hit the U.S. market in 1951, addiction pharmacotherapy was underwhelming for many years. Methadone (Dolophine) eventually arrived...

Alcoholics Anonymous (AA), the biggest self-help group for alcoholics not only in the United States but in the world, was founded in 1935 by Bill Wilson. Wilson—known as Bill W in keeping with the AA tradition of Anonymity—was a successful stockbroker who was also an alcoholic. He sought treatment in...

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