Edmund S. Higgins, MD. Affiliate Associate Professor, Psychiatry and Behavioral Sciences, Medical University of South Carolina. Emily S. Whisler, DO. Child & Adult Psychiatry Fellow, Stanford University School of Medicine. The authors have no financial relationships with companies related to this material.

Sin Yan Lo, PMHNP-BC. Ms. Lo has no financial relationships with companies related to this material.

Xavier Preud’homme, MD. Dr. Preud’homme has no financial relationships with companies related to this material.

Kamron Fariba, DO. Dr. Fariba has no financial relationships with companies related to this material.

Michael Posternak, MD. Dr. Posternak has no financial relationships with companies related to this material.

Glen Spielmans, PhD. Dr. Spielmans has no financial relationships with companies related to this material.

Marilyn J. Vaché, MD. Dr. Vaché has no financial relationships with companies related to this material.

Jesse Koskey, MD. Associate Clinical Professor, Department of Psychiatry and Behavioral Sciences, UC Davis Health, Sacramento, CA.

Dr. Koskey has no financial relationships with companies related to this material.

Margo C. Funk, MD, MA, FACLP.

Director of Cardiovascular Psychiatry, Vice Chair for Education, Residency Program Director, Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA.

Dr. Funk has disclosed that in 2021, she received fees as a consultant for Acadia Pharmaceuticals. Dr. Aiken has reviewed this educational activity and has determined that there is no commercial bias as a result of this financial relationship.

“About half of older adults with depression have evidence of a vascular contribution [to the mood disorder] on MRI, and the rate goes up with age.”