Gastric hypomotility is a common clozapine side effect that can develop into the potentially lethal condition of paralytic ileus. Dr. Aiken’s covered these risks in The Carlat Psychiatry Report. Here’s what you need to know.Dangers of Paralytic Ileus: Hypomotility is very common. Clozapine is the worst offender out of any...

The FDA recently raised alerts about a potentially fatal side effect on clozapine that’s causing more fatalities than neutropenia. It’s constipation, and the problem extends to a few other psychotropics as well. In this article, a three step, evidence-based algorithm for managing it.

We're supposed to move to clozapine after two failed antipsychotics in schizophrenia, but how many of us are really doing that?  Not enough. Clozapine may be difficult to use, but it is life changing for many patients. Here we bring you 7 tips, from serum plasma levels to little-known side...

According to most treatment guidelines, you should consider clozapine after inadequate response to at least two antipsychotics. For patients who are extremely aggressive or suicidal, the APA treatment guidelines state that a trial of clozapine may be reasonable as a first or second line antipsychotic. Here are some additional tips...