Most psychiatrists have at least heard of pramipexole (Mirapex) by now, and many of us have actually prescribed it. The Journal of Clinical Psychiatry recently published a short and sweet review of its potential uses in psychiatry.

Researchers randomly assigned 202 depressed older adults (average age, 53 years old, 75% women) to four conditions: supervised group exercise 3 times a week, at-home aerobic exercise (unsupervised),
sertraline, 50-200 mg/day, or placebo.