The coronavirus can penetrate the brain, causing delirium, psychosis, and persistent cognitive problems in patients with COVID-19.

Lithium has antiviral effects, but its role in COVID-19 is undetermined. 1 in 3 patients with bipolar disorder are excellent lithium responders.

Delusional disorder requires more than medication. Antipsychotics have limited efficacy here, and pimozide is no longer the treatment of choice.