When Prozac first appeared, it was a wonder drug--effective, well-tolerated, and safe in overdose. And, said Eli Lilly, only 1.9% of patients in the clinical trials suffered sexual dysfunction as a side effect. Clinicians weren't so sure about that figure. By 1990, two published case series reported about 8% of patients with delayed orgasm or anorgasmia, and in a 1992 study, 34% of the patients reported some kind of sexual dysfunction. A 1997 study reported rates as high as 86%. What to do? Well, TCR has addressed the problem of SSRI-induced sexual dysfunction (TCR, June 2003) but some have gone one step further: if these drugs delay orgasm, they reason, why not use them to treat premature ejaculation? Recent studies have indeed suggested some benefit, and industry, of course, is not far behind-- Johnson & Johnson and ALZA Corporation are now developing dapoxetine, a fast-acting SSRI to be marketed specifically as a treatment for premature ejaculation. If you can't beat 'em…

Sources: http://www.hsph.harvard.edu/Organizations/DDIL/SSRI.htm; http://www.orthomcneil.com/news/article051004.html