Aloys Alzheimer was a German neurohistologist who was such a workaholic that he would examine brain tissue throughout the night, catching a few hours of sleep the next day before beginning all over again. His boss at the Heidelberg Clinic was none other than Emil Kraepelin (see TCR 1:9). In 1907 Alzheimer examined the brain of a 51 year-old woman who had arrived at the Clinic five years earlier with memory problems, and who had deteriorated rapidly since then. Under the microscope, Alzheimer discovered the now infamous plaques and tangles; however, it was actually Kraepelin who generated the concept that this represented a specific disease entity, and who gave it the nickname “Alzheimer’s Disease.” The name stuck, and catapulted an otherwise obscure histologist to a level of name recognition that will forever elude Kraepelin.