Concerta Fact Sheet
McNeil, marketing exclusivity expires 2008
Attention Deficit Hyperactivity Disorder in children and adolescents
Blocks reuptake of norepinephrine and dopamine
Supplied as 18 mg yellow, 27 mg gray, 36 mg white, and 54 mg brownish-red tablets (not breakable due to extended release vehicle).
Start at 18 mg QAM, and increase gradually to achieve a response.
Maximum recommended dose 54 mg in children, 72 mg in adults.
Most common are decreased appetite, weight loss, tics, and nausea.
- All stimulants are required to carry a warning about the possibility of sudden death, primarily in children with pre-existing cardiac abnormalities.
- Risk of stimulant abuse and diversion (Schedule II controlled substance).
- Growth suppression, usually mild, is possible with all stimulants.
- Pregnancy Category C.
Avoid in combination with MAOIs.
Metabolized by the liver.
- Lasts 8-12 hours.
- Half-life is 3-4 hours.
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