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Saphris and Fanapt: Two New Antipsychotics

You've probably heard about Fanapt (iloperidone) and Saphris (asenapine), two antipsychotics that have recently won FDA approval for the acute treatment of schizophrenia, and, in the case of Saphris, for the treatment of manic and mixed episodes of bipolar disorder. Are these more “me too”...

Typical Antipsychotics: A Brief Review

Those of us who completed residency anytime during the last 10 years were indoctrinated against the use of conventional neuroleptics because of their array of side effects, particularly extrapyramidal syndromes (EPS) and tardive dyskinesia (TD).

The CATIE Trial: The Story is in the Dosing

Few clinical trials have ever generated as much buzz as the series of trials known as CATIE. CATIE stands for “Clinical Antipsychotic Trials of Intervention Effectiveness,” and is the only set of trials ever done comparing the major second-generation antipsychotics. And because CATIE is funded entirely by NIMH, its results are thought to be quite trustworthy (NEJM 2005;353:1209-1223).

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Psychiatry in the News

To help members of the general public understand the sometimes complicated world of psychiatry, TCPR publisher and editor-in-chief Dr. Daniel Carlat has joined AOL Health as their mental health expert and blogger. You can read his AOL blog here.