Antidepressants

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Do Antidepressants Cause Switching?

The latest foray into the controversial issue of antidepressant-induced switching appeared in the February issue of The American Journal of Psychiatry (2006;163:232-239). The last time TCPR took up this topic (June 2005), we reviewed a meta-analysis of antidepressant use in bipolar disorder. That paper concluded that SSRIs cause the same rate of manic switching as placebo (Am J Psychiatry 2004;161:1537-1547). The authors of the newly published research would beg to differ.

Antidepressants: Does Mechanism Matter?

While it’s certainly interesting to theorize about neurotransmitters and antidepressants, the recent STAR*D findings bring up a difficult topic: Does mechanism matter?

How to Bring STAR*D Techniques into Your Practice

Because the first results from STAR*D make antidepressants look less powerful than we might have hoped, researchers have emphasized another aspect of the study – namely, that it represents a system that allows us to bring research techniques into our practices. A review of the STAR*D treatment manual is a useful exercise.
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Research Update

Exercise may be as effective as sertraline

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Exercise may be as effective as sertraline

Confusing presentation of data leads to premature condemnation of black box warnings

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Confusing presentation of data leads to premature condemnation of black box warnings
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Expert QA

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Medication Fact Sheet

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